Antineoplastons

Antineoplaston (ANP) is a name coined by Stanislaw Burzynski for a group of peptides, derivatives, and mixtures for which he claims anti-cancer activity. These compounds have been administered by Burzynski to cancer patients since 1976. The clinical efficacy of antineoplastons combinations for various diseases are the current subject of numerous FDA Phase II trials by Burzynski and his associates. Antineoplastons are manufactured at a facility in Stafford, Texas for investigational use by the Burzynski Clinic, a public company that trades as a penny stock on the OTC Bulletin Board (BZYR)

Background

In 1967 Stanislaw Burzynski began investigating the use of antineoplastons after noting significant peptide deficiencies in the blood of cancer patients as compared with a control group[1][1]. Burzynski first identified antineoplastons from human blood. Since similar peptides had been isolated from urine, in 1970 Burzynski initially purified urine as a bulk source of antinoeplastons. Since 1980 he has been reproducing his compounds synthetically.[2] Since his initial discovery, Burzynski has isolated dozens of peptide and derivatives, some of which have been reportedly found to be active against cancer with low toxicity.

The first active peptide fraction identified was called antineoplaston A-10 (3-phenylacetylamino-2,6-piperidinedione). From A-10, antineoplaston AS2-1, a 4:1 mixture of phenylacetic acid and phenylacetylglutamine, was derived [3]. The active ingredient of antineoplaston A10-I is phenylacetylglutamine [4].
Phenylacetic acid is a toxic compound that the body produces during normal metabolism. It is detoxified in the liver to phenylacetyl glutamine. The "antineoplaston A-10" compound is an isolation artifact resulting from heating the urine under acidic conditions. The "antineoplaston AS2-1" mixture is the result of an alkaline hydrolysis of "antineoplaston A-10". All compounds are widely available cheap chemicals.

Here is the link to Stanislaw Burzynski's Antineoplaston Therapy web site:

http://www.rexresearch.com/burzynski/burzynski.htm  

The FDA and the Texas Medical Board have done eveything in their power to ruin Dr Burzynski. They have persued with irrational verve and vigor withoout success. He has had to appear before 5 Grand Juries to defend his treatment protocol the latest being in April this year (2012). There has not been one indictment to date. They have put him through purgatory beyon belief. Here is a link detailing some of the FDA's heinous activities: 

http://www.dwij.org/pathfinders/dan_haley/dan_2.html